If you've been researching ways to improve your skin without looking overfilled or unnatural, you've probably come across Polynucleotide Skin Boosters.
Over the last few years, Polynucleotide treatments have become one of the biggest advances in regenerative aesthetics. Rather than simply adding volume or temporarily masking signs of ageing, they work by encouraging your skin to repair and regenerate itself from within.
At YBC London, Polynucleotide treatments form part of our philosophy of natural-looking rejuvenation. Instead of changing the way you look, our aim is to improve the quality, strength and health of your skin, allowing you to look fresher, healthier and more confident.
In this guide, we'll explain exactly what Polynucleotides are, how they work, who they're suitable for and what results you can expect.
What Are Polynucleotide Skin Boosters?
Polynucleotides are highly purified fragments of DNA that help stimulate your skin's natural repair processes.
Once carefully injected beneath the skin, they encourage your body's own regenerative mechanisms by supporting fibroblast activity. Fibroblasts are the cells responsible for producing collagen and elastin, two proteins that keep skin firm, smooth and youthful.
Unlike dermal fillers, Polynucleotides don't add volume.
Instead, they improve the overall quality of your skin by helping it become healthier from within.
This means improvements in:
- Skin texture
- Hydration
- Elasticity
- Fine lines
- Skin firmness
- Overall skin quality
Rather than looking like you've had "work done", most patients simply look refreshed and well-rested.
How Do Polynucleotides Work?
As we age, collagen production naturally slows.
From our mid-twenties onwards, collagen production begins to decline, leading to thinner skin, fine lines, loss of elasticity and reduced hydration.
Polynucleotide Skin Boosters work by encouraging the skin to regenerate naturally.
Following treatment, they help to:
- Stimulate collagen production
- Support elastin formation
- Improve blood circulation
- Increase skin hydration
- Reduce inflammation
- Encourage tissue repair
The result is healthier, stronger skin that continues improving over the weeks following treatment.
Because your own skin is doing the work, results develop gradually and naturally.
What Skin Concerns Can Polynucleotides Treat?
One of the reasons Polynucleotides have become so popular is their versatility.
They can improve a wide range of concerns including:
Fine Lines
Improved collagen production helps soften early signs of ageing.
Thin, Crepey Skin
They are particularly effective for delicate areas where traditional fillers may not be appropriate.
Dull Skin
Many patients notice brighter, healthier-looking skin after completing their treatment course.
Dehydrated Skin
The skin often feels more hydrated and resilient.
Acne Scarring
By encouraging tissue repair, Polynucleotides can improve mild textural scarring.
Sun Damage
Although they won't completely remove pigmentation, healthier skin often appears smoother and more even.
Skin Laxity
Improved collagen can increase firmness and elasticity over time.
Which Areas Can Be Treated?
Polynucleotide Skin Boosters can be used on several areas of the body.
Common treatment areas include:
- Face
- Under eyes
- Neck
- Décolletage
- Hands
At YBC London, we frequently treat the face, neck and eye area together to create balanced, natural rejuvenation.
Are Polynucleotides Better Than Dermal Fillers?
They aren't better—they simply do different jobs.
Dermal fillers restore lost volume.
Polynucleotides improve skin quality.
Many patients benefit from combining both treatments as part of a personalised treatment plan.
For example:
- Polynucleotides improve skin health.
- Dermal fillers restore facial structure.
- Anti-wrinkle injections soften expression lines.
Together, these treatments can create subtle, natural-looking results.
What Happens During Treatment?
Your appointment begins with a detailed consultation to assess your skin concerns, medical history and long-term goals.
Treatment itself usually takes around 30–45 minutes.
Tiny injections are placed beneath the skin using a very fine needle.
Most patients describe the discomfort as minimal.
Following treatment you may notice:
- Small injection marks
- Mild swelling
- Slight redness
These effects usually settle within a few days.
How Many Treatments Will I Need?
For optimal results, most patients benefit from a course of treatments.
This is because collagen stimulation happens gradually.
Your treatment plan will always be tailored to your individual skin concerns, but many patients achieve the best results with an initial course followed by maintenance appointments.
Consistency is one of the biggest factors in achieving long-term improvements in skin quality.
At YBC London, we often remind patients that healthy skin isn't achieved in a single appointment—it's built over time.
When Will I See Results?
Unlike fillers, results are not immediate.
Most patients notice:
- Improved hydration within the first few weeks
- Better skin texture after several weeks
- Increased firmness over the following months
Because collagen production continues after treatment, results often keep improving over time.
How Long Do Results Last?
Results vary depending on age, lifestyle and skin condition.
Factors such as smoking, sun exposure, nutrition and skincare all influence how long results last.
Regular maintenance treatments help preserve improvements and continue supporting collagen production.
Who Is Suitable for Polynucleotide Skin Boosters?
Polynucleotides are suitable for many adults looking to improve overall skin quality.
You may be a good candidate if you:
- Are concerned about ageing skin
- Want natural-looking rejuvenation
- Have dehydrated skin
- Notice loss of elasticity
- Want healthier-looking skin without adding volume
During your consultation, we'll assess your skin and recommend whether Polynucleotides are the most suitable option or whether another treatment may better achieve your goals.
Aftercare
Following treatment we generally recommend:
- Avoid strenuous exercise for 24 hours.
- Avoid excessive heat, including saunas and steam rooms.
- Avoid touching or massaging the treated area.
- Follow any personalised aftercare advice provided by your practitioner.
- Wear SPF daily to help protect your skin.
Supporting your skin from the inside is just as important as treating it externally. Staying hydrated, eating a balanced diet and following a consistent skincare routine can all help optimise your results.
Frequently Asked Questions
Are Polynucleotides safe?
When performed by a qualified medical professional using clinically approved products, Polynucleotide treatments have an excellent safety profile. Your suitability will always be assessed during your consultation.
Are they the same as Profhilo?
No. While both treatments aim to improve skin quality, they work differently. Profhilo primarily hydrates the skin using hyaluronic acid, whereas Polynucleotides focus on stimulating the skin's natural repair and collagen production.
Do Polynucleotides hurt?
Most patients find the treatment very manageable. A topical numbing cream can be used if appropriate to help maximise comfort.
Can Polynucleotides replace fillers?
Not usually. Polynucleotides improve skin quality rather than restoring lost volume. Many patients achieve the best results by combining different treatments as part of a personalised treatment plan.
How long does treatment take?
Most appointments take around 30 to 45 minutes, depending on the areas being treated.
Can they be used around the eyes?
Yes. Polynucleotides are particularly popular for the delicate under-eye area, where they can help improve skin quality, hydration and fine lines without adding volume.
Why Choose YBC London for Polynucleotide Treatments?
At YBC London, every treatment begins with understanding your individual goals. Rather than taking a one-size-fits-all approach, we create personalised treatment plans designed to enhance your natural features and improve your skin over time.
Our focus is on regenerative aesthetics—supporting your skin's health from within using evidence-based treatments and a long-term approach to rejuvenation. Whether you're looking to improve skin quality, restore hydration or address the early signs of ageing, we'll recommend the most appropriate treatment for your needs.
Many of our patients choose to combine Polynucleotide Skin Boosters with other treatments as part of our signature treatment plans, helping to achieve balanced, natural-looking results that continue to improve with consistency.